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Faculty of Science, Mahidol University's Awards

      

 
Professor Dr. Pramuan Tangboriboonrat
TRF Senior Research Scholar Year 2008

 

Biography and Research Summary


 

Professor Dr. Pramuan Tangboriboonrat was born on December 27, 1962 in Prachinburi province. She finished primary and secondary education in her hometown and the high school study from Wattana Wittaya Academy in Bangkok. Professor Pramuan received her B.Sc. (first class honours) in Chemistry from Khon Kaen University in 1983 and M.Sc. in Physical Chemistry from Mahidol University in 1986 (receiving Awards from the Professor Dr. Tab Nilanidhi Foundation at the B.Sc. and M.Sc. levels). She obtained a scholarship from the French Government to pursue her Ph.D. at Université de Haute Alsace, Ecole Nationale Supérieure de Chimie de Mulhouse, France. Professor Pramuan received the DiplÔme Elémentaire de la Langue Française (DELF) from CAVILAM, Vichy in 1987, DiplÔme D’Etude Applofondie (DEA in Chimie Physique) in 1988 and Docteur (Chimie Macromoléculaire) in 1991. After graduation, Professor Pramuan joined the Department of Chemistry, Faculty of Science, Mahidol University where she was promoted to Assistant Professor, Associate Professor and Professor in 1994, 1997 and 2004 respectively.


 

Professor Pramuan won the Outstanding Young Scientist Award from the Foundation for the Promotion of Science and Technology under the Patronage of H.M. the King in 1996 and the L’OREAL-UNESCO Fellowship for Women in Science in 2007. She received research grants from Mahidol University, the National Metal and Materials Technology Centre, the ENO Science Foundation (Japan) and the Thailand Research fund (TRF). In 2008, she received the TRF Senior Research Scholar sponsored by TRF and the Commission on Higher Education.


 

For her work experience, Professor Pramuan served as Secretary of the Thailand Academy of Science and Technology (2003-2006), Assistant to the President of the National Science and Technology Development Agency (2006-2008), and Secretary to the Minister of Science and Technology (October 2006-January 2008). At present, she is a member of the Academic Review Committees of Sirindhorn International Institute of Technology, Thammasat University; Rajamangala University of Technology Phra Nakhon and North Bangkok College.


 

Professor Tangboriboonrat’s research work involves the study of the structure and composition of natural rubber (NR) latex particle surfaces to lead to novel utilization of the latex and, hence, to innovative, value-added rubber products. Her simple and straight-forward process, i.e., the phase transfer/bulk or suspension polymerization/ TEM technique, is applied to reveal the cross-linking in each prevulcanized NR particle. Not only does the method provide direct evidence of the particle morphology, but it can also be used for the preparation of high impact polystyrene. Moreover, the heterocoagulation of NR particles with polychloroprene of skim NR particles is efficiently adapted for the preparation of composite particles with a core-shell structure. Capsules of urea/NR or skim latex and beads of carbon black/NR latex masterbatch have been also prepared. Recently, with the aim of reducing the surface friction or tack of NR sheets, an increase in surface roughness and hardness of the dried rubber product has been achieved by depositing poly(methyl methacrylate) (PMMA) nanoparticles or by polymerization of PMMA on the rubber substrate. The process of replacement of PMMA particles with antiseptic nanocapsules is under investigation in order to prepare NR latex medical gloves. In addition, a well characterized polystyrene/acrylic acid copolymer latex particle has been used as a solid support for P. falciparum malaria protein antigens or antibodies to P. falciparum malaria for the latex agglutination test.


 

Future research and development will cover the above mentioned areas, but to a greater depth and wider application, especially in biomedical fields. These are:

 

1. Preparation of soft poly(methyl acrylate) (PMA) capsules containing antiseptic agent. The aim is to fabricate three-layer medical gloves of prevulcanized NR/antiseptic agent-PMA capsules/prevulcanized NR. The heterocoagulated particles composed of skim NR latex particles surrounding antiseptic agent-PMA capsules will be also prepared and then used for deposition onto a prevulcanized NR film as a bilayer structure.


 

2. Study of rubber-based biomedical materials utilizing the attachment of functionalized or bioactive polymers on the rubber surface. The functionalized polymers are also applied as interfacial materials for the inclusion of proteins or bio-molecules on the surface of magnetic polymeric particles for use in protein separation applications and/or protein-specific decease diagnostics. A highly sensitive and selective polymeric probe that could be employed in a non-enzymatic bioassay will developed.


 

3. Development of nanofibers from degradable polymers, e.g., polylactic acia (PLA), poly(lactic acie-co-ethylene glycol) (PLA-co-PEG), and PLA/PEG blends by using an electrospinning technique. The nanofibers will be used as drug controlled-release materials. Feasibility of using the nanofibers in cell culture applications or as scaffolds is assessed. In addition, the polymers are used to modify and enhance rubber’s properties for potential medical applications as pressure-sensitive patches.